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Department of Neuroscience
BMC, Box 593
751 24 UPPSALA

 

 

Tel: +4618-471 4326

 

christian.benedict@neuro.uu.se

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© 2019 by Lieve van Egmond. Created with Wix.com

publications

  1. Tan X, Cook JD, Cedernaes J, Benedict C. Consumer sleep trackers: a new tool to fight the hidden epidemic of obstructive sleep apnoea? Lancet Resp Med, accepted.
     

  2. Tan X, Ciuculete DM, Schiöth HB, Benedict C. Associations between chronotype, MTNR1B genotype, and risk of type 2 diabetes in UK Biobank. J Intern Med. 2019 Oct 17. doi: 10.1111/joim.12994
     

  3. Titova OE, Lindberg E, Tan X, Elmståhl S, Lind L, Schiöth HB, Benedict C. Association between sleep duration and executive function differs between diabetic and non-diabetic middle-aged and older adults. Psychoneuroendocrinology. 2019 Oct 3;111:104472.
     

  4. van Egmond L, Tan X, Sjögren P, Cederholm T, Benedict C. Association between Healthy Dietary Patterns and Self-Reported Sleep Disturbances in Older Men: The ULSAM Study. Nutrients. 2019;11(5). pii: E1029.
     

  5. Tan X, Cedernaes J, Risérus U, Benedict C. Lack of association between self-reported insomnia symptoms and clamp-derived insulin sensitivity in elderly men. Psychoneuroendocrinology. 2019;102:256-260.
     

  6. van Egmond L, Ekman M, Benedict C. Bed and rise times during the Age of Enlightenment: a case report. J Sleep Res 2019; 
     

  7. Dyakova O, Rångtell FH, Tan X, Nordström K, Benedict C. Acute sleep loss induces signs of visual discomfort in young men. J Sleep Res. 2019:e12837.
     

  8. Tan X, Titova OE, Lindberg E, Elmståhl S, Lind L, Schiöth HB, Benedict C. Association Between Self-Reported Sleep Duration and Body Composition in Middle-Aged and Older Adults. J Clin Sleep Med. 2019;15(3):431-435.
     

  9. Rångtell FH, Karamchedu S, Andersson P, Liethof L, Olaya Búcaro M, Lampola L, Schiöth HB, Cedernaes J, Benedict C. A single night of sleep loss impairs objective but not subjective working memory performance in a sex-dependent manner. J Sleep Res. 2019;28(1):e12651.
     

  10. Tan X, van Egmond L, Partinen M, Lange T, Benedict C. Response to comment on “A narrative review of interventions for improving sleep and reducing circadian disruption in medical inpatients”. Sleep Med., 2019, accepted. [Epub ahead of print]
     

  11. Tan X, van Egmond L, Partinen M, Lange T, Benedict C. A narrative review of interventions for improving sleep and reducing circadian disruption in medical inpatients. Sleep Med 2018, accepted. [Epub ahead of print]
     

  12. Cedernaes J, Schönke M, Westholm JO, Mi J, Chibalin A, Voisin S, Osler M, Vogel H, Hörnaeus K, Dickson L, Lind SB, Bergquist J, Schiöth HB, Zierath JR, Benedict C. Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans. Sci Adv. 2018;4(8):eaar8590.
     

  13. Titova OE, Lindberg E, Elmståhl S, Lind L, Schiöth HB, Benedict C. Associations Between the Prevalence of Metabolic Syndrome and Sleep Parameters Vary by Age. Front Endocrinol (Lausanne). 2018;9:234.
     

  14. Tan X, Cedernaes J, Forsberg LA, Schiöth HB, Benedict C. Self-reported sleep disturbances and prostate cancer morbidity and mortality in Swedish men: A longitudinal study over 40 years. J Sleep Res. 2018:e12708.
     

  15. Tan X, Benedict C. Association between high-glycemic diet and cerebral amyloid burden: a possible role for sleep. Am J Clin Nutr. 2018;107(3):480.
     

  16. Cai GH, Janson C, Theorell-Haglöw J, Benedict C, Elmståhl S, Lind L, Lindberg E. Both Weight at Age 20 and Weight Gain Have an Impact on Sleep Disturbances Later in Life: Results of the EpiHealth Study. Sleep. 2018;41(1).
     

  17. Chapman CD, Benedict C, Schiöth HB. Experimenter gender and replicability in science. Sci Adv. 2018;4(1):e1701427.
     

  18. Tan X, Chapman CD, Cedernaes J, Benedict C. Association between long sleep duration and increased risk of obesity and type 2 diabetes: A review of possible mechanisms. Sleep Med Rev. 2018;40:127-134.
     

  19. Rångtell FH, Schmidt F, Würfel J, Karamchedu S, Andersson P, Vogel H, Benedict C. Morning Enzymatic Activity of DPP-4 Is Differentially Altered by Sleep Loss in Women and Men. Diabetes Care. 2018;41(2):e10-e11.
     

  20. Rångtell FH, Karamchedu S, Andersson P, van Egmond L, Hultgren T, Broman JE, Cedernaes J, Benedict C. Learning performance is linked to procedural memory consolidation across both sleep and wakefulness. Sci Rep. 2017;7(1):10234.
     

  21. Tan X, van Egmond L, Chapman CD, Cedernaes J, Benedict C. Aiding sleep in type 2 diabetes: therapeutic considerations. Lancet Diabetes Endocrinol. 2018;6(1):60-68.
     

  22. Chapman CD, Benedict C, Schiöth HB. Sex matters: Report experimenter gender. Science. 2017;356(6341):916-917.
     

  23. Thienel M, Wilhelm I, Benedict C, Born J, Hallschmid M. Intranasal insulin decreases circulating cortisol concentrations during early sleep in elderly humans. Neurobiol Aging. 2017;54:170-174.
     

  24. Benedict C, Vogel H, Jonas W, Woting A, Blaut M, Schürmann A, Cedernaes J. Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals. Mol Metab. 2016;5(12):1175-1186.
     

  25. Cedernaes J, Fanelli F, Fazzini A, Pagotto U, Broman JE, Vogel H, Dickson SL, Schiöth HB, Benedict C. Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans. Psychoneuroendocrinology. 2016;74:258-268.
     

  26. Rångtell FH, Ekstrand E, Rapp L, Lagermalm A, Liethof L, Búcaro MO, Lingfors D, Broman JE, Schiöth HB, Benedict C. Two hours of evening reading on a self-luminous tablet vs. reading a physical book does not alter sleep after daytime bright light exposure. Sleep Med. 2016;23:111-118.
     

  27. Titova OE, Lindberg E, Elmståhl S, Lind L, Schiöth HB, Benedict C. Association between shift work history and performance on the trail making test in middle-aged and elderly humans: the EpiHealth study. Neurobiol Aging. 2016;45:23-29.
     

  28. Cedernaes J, Osorio RS, Varga AW, Kam K, Schiöth HB, Benedict C. Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease. Sleep Med Rev. 2017;31:102-111.
     

  29. Cedernaes J, Sand F, Liethof L, Lampola L, Hassanzadeh S, Axelsson EK, Yeganeh A, Ros O, Broman JE, Schiöth HB, Benedict C. Learning and sleep-dependent consolidation of spatial and procedural memories are unaltered in young men under a fixed short sleep schedule. Neurobiol Learn Mem. 2016;131:87-94.
     

  30. Benedict C. Antihypertensive medication prior to nocturnal sleep reduces the risk of new-onset type 2 diabetes in hypertensive patients: a role for slow-wave sleep? Diabetologia. 2016;59(2):390-1.
     

  31. Feld GB, Wilhem I, Benedict C, Rüdel B, Klameth C, Born J, Hallschmid M. Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation. Neuropsychopharmacology. 2016;41(6):1540-50.
     

  32. Cedernaes J, Lampola L, Axelsson EK, Liethof L, Hassanzadeh S, Yeganeh A, Broman JE, Schiöth HB, Benedict C. A single night of partial sleep loss impairs fasting insulin sensitivity but does not affect cephalic phase insulin release in young men. J Sleep Res. 2016;25(1):5-10.
     

  33. Cedernaes J, Osler ME, Voisin S, Broman JE, Vogel H, Dickson SL, Zierath JR, Schiöth HB, Benedict C. Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men. J Clin Endocrinol Metab. 2015;100(9):E1255-61.
     

  34. Cedernaes J, Rångtell FH, Axelsson EK, Yeganeh A, Vogel H, Broman JE, Dickson SL, Schiöth HB, Benedict C. Short Sleep Makes Declarative Memories Vulnerable to  Stress in Humans. Sleep. 2015;38(12):1861-8.
     

  35. Cedernaes J, Schiöth HB, Benedict C. Determinants of shortened, disrupted, and mistimed sleep and associated metabolic health consequences in healthy humans. Diabetes. 2015;64(4):1073-80.
     

  36. Titova OE, Hogenkamp PS, Jacobsson JA, Feldman I, Schiöth HB, Benedict C. Associations of self-reported sleep disturbance and duration with academic failure in community-dwelling Swedish adolescents: sleep and academic performance at school. Sleep Med. 2015;16(1):87-93.
     

  37. Benedict C, Byberg L, Cedernaes J, Hogenkamp PS, Giedratis V, Kilander L, Lind L, Lannfelt L, Schiöth HB. Self-reported sleep disturbance is associated with Alzheimer's disease risk in men. Alzheimers Dement. 2015;11(9):1090-7.
     

  38. Benedict C, Axelsson T, Söderberg S, Larsson A, Ingelsson E, Lind L, Schiöth HB. Fat mass and obesity-associated gene (FTO) is linked to higher plasma levels of the hunger hormone ghrelin and lower serum levels of the satiety hormone leptin in older adults. Diabetes. 2014;63(11):3955-9.
     

  39. Christoffersson G, Vågesjö E, Pettersson US, Massena S, Nilsson EK, Broman JE, Schiöth HB, Benedict C, Phillipson M. Acute sleep deprivation in healthy young men: impact on population diversity and function of circulating neutrophils. Brain Behav Immun. 2014;41:162-72.
     

  40. Cedernaes J, Brandell J, Ros O, Broman JE, Hogenkamp PS, Schiöth HB, Benedict C. Increased impulsivity in response to food cues after sleep loss in healthy young men. Obesity (Silver Spring). 2014;22(8):1786-91.
     

  41. Benedict C, Cedernaes J, Giedraitis V, Nilsson EK, Hogenkamp PS, Vågesjö E, Massena S, Pettersson U, Christoffersson G, Phillipson M, Broman JE, Lannfelt L,  Zetterberg H, Schiöth HB. Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men. Sleep. 2014;37(1):195-8.
     

  42. Benedict C. Link between short sleep and obesity in humans: a matter of age? Chest. 2013;144(2):711.
     

  43. Chapman CD, Nilsson EK, Nilsson VC, Cedernaes J, Rångtell FH, Vogel H, Dickson SL, Broman JE, Hogenkamp PS, Schiöth HB, Benedict C. Acute sleep deprivation increases food purchasing in men. Obesity (Silver Spring). 2013;21(12):E555-60.
     

  44. Hogenkamp PS, Nilsson E, Chapman CD, Cedernaes J, Vogel H, Dickson SL, Broman JE, Schiöth HB, Benedict C. Sweet taste perception not altered after acute sleep deprivation in healthy young men. Somnologie (Berl). 2013;17(2):111-114.
     

  45. Benedict C, Barclay JL, Ott V, Oster H, Hallschmid M. Acute sleep deprivation delays the glucagon-like peptide 1 peak response to breakfast in healthy men. Nutr Diabetes. 2013;3:e78.
     

  46. Freiherr J, Hallschmid M, Frey WH 2nd, Brünner YF, Chapman CD, Hölscher C, Craft S, De Felice FG, Benedict C. Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS Drugs. 2013;27(7):505-14.
     

  47. Herzog N, Jauch-Chara K, Hyzy F, Richter A, Friedrich A, Benedict C, Oltmanns KM. Selective slow wave sleep but not rapid eye movement sleep suppression impairs morning glucose tolerance in healthy men. Psychoneuroendocrinology. 2013;38(10):2075-82.
     

  48. Hogenkamp PS, Nilsson E, Nilsson VC, Chapman CD, Vogel H, Lundberg LS, Zarei S, Cedernaes J, Rångtell FH, Broman JE, Dickson SL, Brunstrom JM, Benedict C*, Schiöth HB*. Acute sleep deprivation increases portion size and affects food choice in young men. Psychoneuroendocrinology. 2013;38(9):1668-74. *shared seniors
     

  49. Schiöth HB, Chapman CD, Benedict C. To sleep or not to sleep: do we forget our patient's sleep? Arch Intern Med. 2012;172(9):746.
     

  50. Herzog N, Friedrich A, Fujita N, Gais S, Jauch-Chara K, Oltmanns KM, Benedict C. Effects of daytime food intake on memory consolidation during sleep or sleep deprivation. PLoS One. 2012;7(6):e40298.
     

  51. Schiöth HB, Brooks SJ, Benedict C. Healthcare systems never sleep: are medical residents today the patients of tomorrow? Sleep Med. 2012;13(7):965. 
     

  52. Benedict C, Brooks SJ, Kullberg J, Burgos J, Kempton MJ, Nordenskjöld R, Nylander R, Kilander L, Craft S, Larsson EM, Johansson L, Ahlström H, Lind L, Schiöth HB. Impaired insulin sensitivity as indexed by the HOMA score is associated with deficits in verbal fluency and temporal lobe gray matter volume in the elderly. Diabetes Care. 2012;35(3):488-94.
     

  53. Herzog N, Jauch-Chara K, Oltmanns KM, Benedict C. Compromised sleep increases food intake in humans: two sexes, same response? Am J Clin Nutr. 2012;95(2):531.
     

  54. Benedict C, Brooks SJ, O'Daly OG, Almèn MS, Morell A, Åberg K, Gingnell M, Schultes B, Hallschmid M, Broman JE, Larsson EM, Schiöth HB. Acute sleep deprivation enhances the brain's response to hedonic food stimuli: an fMRI study. J Clin Endocrinol Metab. 2012;97(3):E443-7.
     

  55. Benedict C, Brytting M, Markström A, Broman JE, Schiöth HB. Acute sleep deprivation has no lasting effects on the human antibody titer response following a novel influenza A H1N1 virus vaccination. BMC Immunol. 2012;13:1.
     

  56. Bollinger T, Leutz A, Leliavski A, Skrum L, Kovac J, Bonacina L, Benedict C, Lange T, Westermann J, Oster H, Solbach W. Circadian clocks in mouse and human CD4+ T cells. PLoS One. 2011;6(12):e29801.
     

  57. Benedict C, Shostak A, Lange T, Brooks SJ, Schiöth HB, Schultes B, Born J, Oster H, Hallschmid M. Diurnal rhythm of circulating nicotinamide phosphoribosyltransferase (Nampt/visfatin/PBEF): impact of sleep loss and relation to glucose metabolism. J Clin Endocrinol Metab. 2012;97(2):E218-22.
     

  58. Benedict C, Hallschmid M, Lassen A, Mahnke C, Schultes B, Schiöth HB, Born J, Lange T. Acute sleep deprivation reduces energy expenditure in healthy men. Am J Clin Nutr. 2011;93(6):1229-36.
     

  59. Schmid SM, Hallschmid M, Jauch-Chara K, Wilms B, Benedict C, Lehnert H, Born J, Schultes B. Short-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men. Am J Clin Nutr. 2009;90(6):1476-82.
     

  60. Benedict C, Scheller J, Rose-John S, Born J, Marshall L. Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep. FASEB J. 2009;23(10):3629-36.
     

  61. Dimitrov S, Benedict C, Heutling D, Westermann J, Born J, Lange T. Cortisol and epinephrine control opposing circadian rhythms in T cell subsets. Blood. 2009;113(21):5134-43.
     

  62. Benedict C, Kern W, Schmid SM, Schultes B, Born J, Hallschmid M. Early morning rise in hypothalamic-pituitary-adrenal activity: a role for maintaining the brain's energy balance. Psychoneuroendocrinology. 2009;34(3):455-62.
     

  63. Benedict C, Dimitrov S, Marshall L, Born J. Sleep enhances serum interleukin-7 concentrations in humans. Brain Behav Immun. 2007;21(8):1058-62.
     

  64. Dimitrov S, Lange T, Benedict C, Nowell MA, Jones SA, Scheller J, Rose-John S, Born J. Sleep enhances IL-6 trans-signaling in humans. FASEB J. 2006;20(12):2174-6.
     

  65. Benedict C, Hallschmid M, Hatke A, Schultes B, Fehm HL, Born J, Kern W. Intranasal insulin improves memory in humans. Psychoneuroendocrinology. 2004;29(10):1326-34.

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